According to the Merriam-Webster dictionary, dissolution is defined as “the act or process of dissolving or the state of being dissolved.” In science, dissolution is the process by which one substance (the solute) is broken down and dispersed into another (the solvent). The solute can be a solid, liquid, or gas, while the solvent is usually a liquid.
The Process and Factors Affecting Dissolution
In dissolution, the solute particles separate from each other and are surrounded by solvent molecules.
Temperature is a factor that can affect dissolution by expediting the process. Fillers and binders can also affect the rate of dissolution. The dissolution rate is defined as the rate or speed at which a drug substance dissolves in a medium.
The effect of granule mean diameter (GMD) on dissolution rate was consistent with the observation that tablet dissolution rate was affected by granulation parameters in a direction opposite to their effect on granule GMD. Therefore, increase in water amount used for granulation increased GMD (P < 0.0001) and reduced the percentage dissolved in 30 min (P < 0.0001), while the increase in impeller speed reduced GMD (P = 0.005) and increased dissolution rate (P = 0.009).
The combined effect of pH and temperature on dissolution is modeled by two independent proton promoted reaction paths. The first reaction path controls the overall dissolution rate at pH ≥ 2.5, whereas the second path controls it below pH 0.5.
Methods and Effects of Dissolution
The methods of dissolution are as follows:
- Voluntary dissolution: When the company decides to dissolve itself.
- Involuntary dissolution: When the company is forced to dissolve by a court order or the shareholders decide to dissolve it.
Upon making the decision to dissolve a company, the company must follow wind-up procedures. All debts, liabilities, and affairs must be settled. The company’s legal existence ends when Articles of Dissolution are filed. The terms of existing contracts must be carried out, and agreements cannot be renewed.
Precipitation is the opposite of dissolution. In precipitation, the solute particles find each other and form a solid.